William C. Groutas

Endowment Association's Distinguished Professor

Education

  • Ph.D., University of Kentucky, 1973

Principal Research Interests

  • Structure-based design and synthesis of inhibitors of viral proteases
  • Drug discovery and development of antiviral and antifungal agents
  • Combinatorial chemistry and Mechanistic enzymology

Representative Publications

See All
  1. Kim Y, Lovell S, Tiew K-C, Mandadapu SR, Alliston KR, Battaille KP, Groutas WC, Chang K-O. Broad Spectrum Antivirals Against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses and Coronoviruses. J Virol 86 (2012) 1754-11762.
  2. Alex D, Gay-Andrieu F, May J, Thampi L, Dou D, Mooney A, Groutas WC, Calderone R. Amino Acid-Derived 1,2-Benzisothiazolinone Derivatives as Novel Small Molecule Antifungal Inhibitors: Identification of Potential Genetic Targets. Antimicrob Agents Chemother 56 (2012) 4630-4639.
  3. Kim Y, Mandadapu SR, Groutas WC, Chang K-O. Potent Inhibition of Feline Coronoviruses with Peptidyl Compounds Targeting Coronovirus 3C-like Protease. Antiviral Res 97 (2013)161-168.
  4. Mandadapu SR, Gunnam MR, Tiew K-C, Uy RAZ, Prior AM, Alliston KR, Hua DH, Kim Y, Chang K-O, Groutas WC. Inhibition of Norovirus 3CL Protease by Bisulfite Adducts of Transition State Inhibitors. Bioorg Med Chem Lett 23 (2013) 62-65.
  5. Prior AM, Kim Y, Weerasekara S, Moroze M, Alliston KR, Uy RAZ, Groutas WC, Chang K-O, Hua DH. Design, Synthesis, and Bioevaluation of Viral 3C and 3C-like Protease Inhibitors. Bioorg Med Chem Lett 23 (2013) 6317-6320.
  6. Mandadapu SR, Gunnam MR, Kankanamalage ACG, Uy RAZ, Alliston KR, Lushington GH, Kim Y, Chang K-O, Groutas WC. Potent Inhibition of Norovirus by Dipeptidyl α-Hydroxyphosphonate Transition State Mimics Bioorg Med Chem Lett 23 (2013) 5941-5944.
  7. Mandadapu SR, Weerawarna PM, Prior AM, Uy RAZ, Aravapalli S, Alliston KR, Lushington GH, Kim Y, Hua DH, Chang K-O, Groutas WC. Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus and Coronavirus. Bioorg Med Chem Lett 23 (2013) 3709-3712.
  8. Mandadapu SR, Gunnam MR, Tiew KC, Uy RAZ, Prior AM, Alliston KR, Hua DH, Kim Y, Chang K-O, Groutas WC. Inhibition of Norovirus 3CL Protease by Bisulfite Adducts of Transition State Inhibitors. Bioorg Med Chem Lett 23 (2013) 62-65.
  9. Takahashi D, Kim Y, Lovell S, Prakash O, Groutas WC, Chank K-O. Structural and Inhibitor Studies of Norovirus 3C-Like Proteases. Virus Res. 178 (2013) 437-444.